Sunday, January 14, 2007

Sunday Sign of Hope January 14th 2007

Fifth gene identified in quest to stop Alzheimer's

From TimesOnline:

A new gene that causes Alzheimer’s disease when it malfunctions has been identified, suggesting new approaches to treating the incurable brain condition.

People who inherit a version of a gene known as SORL1 have a higher risk of developing late-onset Alzheimer’s. SORL1 appears to affect how beta amyloid proteins build up in brain cells, which is thought to be the chief cause of Alzheimer’s.

The Alzheimer’s Society said that the research, published in Nature Genetics, was an exciting development. Dementia is well known to be influenced by genetics, and previous research has identified four other genes that are linked to a higher risk. The best known, the apolipoprotein E — or ApoE — gene, comes in three varieties, of which ApoE4 makes people up to ten times more likely to develop Alzheimer’s.

ApoE4, however, is not carried by 60 per cent of Alzheimer’s patients, and scientists have long known that a complex of genes is likely to be involved in the disease. The new research, by a team led by Richard Mayeux, of Columbia University in New York, suggests that SORL1 is one.


Anonymous Anonymous said...

Alzheimer's a sign of hope?
yeah! it's best not to remember all the shit in this world, your last 4 stories went into.

January 18, 2007 1:48 PM  

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